Issues in Calibrations and Accuracy in Method Validation

Why Should You Attend:

Accuracy, the ability for a methodology to give results within acceptable limits when compared to known values, is a fundamental and key requirement. Calibration is the most common approach to obtain accuracy.

Accuracy requires a comparison to a validated material. The level of confidence depends on traceability, a chain connecting the samples of interest all the way to the specific metric standards. This can be a complex task which can raise doubts in an auditor. There are different situations for the use of each of standards of the various types. How to access the validity is a key.

In calibration, fundamental reliance on linearity of response make proof of linearity important. This is more involved that only obtaining a linear regression factor or correlation coefficient. Once proven, though, calibrations can change with various factors. Monitoring calibration behavior and using that to maintain or even improve a methodology can be very useful.

Areas Covered in the Webinar:

• How accuracy is determined
• What are the various types of standards and what are their strengths and weaknesses?
• The importance of traceability
• Calibration curves – what are the important criteria? Linearity versus nonlinearity, slope, intercept and what they mean
• Matrix effects and how to deal with them
• Using calibration data to monitor performance

Who Will Benefit:

• Lab Chemists
• Lab Managers
• Lab Technicians
• Lab Analysts
• Industries into Compliance Methodology (Biotech, Pharma) Companies into Environmental Compliance or EPA